-Methyl-5-HT, a 5-HT2 receptor agonist, stimulates 2-adrenoceptors in guinea pig airway smooth muscle

نویسندگان

  • Patricia Campos-Bedolla
  • Mario H. Vargas
  • Eduardo Calixto
  • Patricia Segura
  • Nicandro Mendoza-Patiño
  • Alejandra Figueroa
  • Edgar Flores-Soto
  • Carlos Barajas-López
  • Luis M. Montaño
چکیده

Patricia Campos-Bedolla a, Mario H. Vargas b, Eduardo Calixto c, Patricia Segura b, Nicandro Mendoza-Patiño e, Alejandra Figueroa e, Edgar Flores-Soto e, Carlos Barajas-López d, Luis M. Montaño e,∗ a Unidad de Investigación Médica en Enfermedades Neurológicas, Instituto Mexicano del Seguro Social, México DF, Mexico b Departamento de Hiperreactividad Bronquial, Instituto Nacional de Enfermedades Respiratorias, México DF, Mexico c Departamento de Neurobiologı́a, Div. Neurociencias, Instituto Nacional de Psiquiatrı́a, México DF, Mexico d División de Biologı́a Molecular, Instituto Potosino de Investigación Cientı́fica y Tecnológica, San Luis Potosı́, SLP, Mexico e Departamento de Farmacologı́a, Facultad de Medicina, Universidad Nacional Autónoma de México, México DF, Mexico

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties.

The objective of the present studies was to characterize the pharmacologic properties of GSK-961081 [TD-5959; (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl) piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate], a novel first-in-class inhaled bifunctional compound possessing both muscarinic antagonist (MA) and β2-ad...

متن کامل

Clonidine-induced coronary vasodilatation in isolated guinea pig heart is not mediated by endothelial alpha2 adrenoceptors.

Functional role of endothelial alpha(2)-adrenoceptor in coronary circulation remains unclear. Clonidine, an agonist of alpha(2)-adrenoceptors, was reported to induce coronary vasodilatation via stimulation of endothelial alpha(2)-adrenoceptors or coronary vasoconstriction involving vascular smooth muscle alpha(2)-adrenoceptors. Moreover, H(2) receptor-dependent responses to clonidine were descr...

متن کامل

5-Hydroxytryptamine4 receptor agonists and colonic motility.

5-Hydroxytryptamine (5-HT) released from enterochromaffin cells regulates gastrointestinal function in either an excitatory or inhibitory manner. 5-HT(3) and 5-HT(4) receptors in the gut have been the focus of clinical studies on the management of gastrointestinal motility disorders. 5-HT stimulates intestinal propulsive reflexes through 5-HT(4) receptors. 5-HT(4) receptor agonists can stimulat...

متن کامل

5-Hydroxytryptamine receptors, especially the 5-HT4 receptor, in guinea pig urinary bladder.

The function of 5-hydroxytryptamine (5-HT) receptors, especially the 5-HT4 receptor, in the urinary bladder were examined in preparations isolated from the guinea pig by in vitro receptor autoradiography and determinations of mechanical activity and acetylcholine (ACh) release. Specific [125I]SB207710 binding sites were detected evenly throughout the urinary bladder. 5-HT (3 x 10(-8)-10(-4) M) ...

متن کامل

Hydro-ethanolic Extract of Portulaca oleracea Affects Beta-adrenoceptors of Guinea Pig Tracheal Smooth Muscle

The stimulatory effect of the extract of Portulaca oleracea (P. olerace) on β-adrenoceptor of tracheal smooth muscle was examined. To examine β-adrenoceptor stimulatory effect, concentration response curve to isoprenaline was obtained in pre-contracted tracheal smooth muscle in the presence of three concentrations of aqueous-ethanolic extract, propranolol and saline. Values of EC50 (the effecti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2006